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	Provedor de dados Genet. Mol. Biol. (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Aissa,Alexandre Ferro (1) Antunes,Lusânia Maria Greggi (1) Bizari,Lucimari (1) Ferreira Jr.,Rui Seabra (1) Machado,Ana Rita Thomazela (1) Ribeiro,Diego Luis (1) Sampaio,Suely Vilela (1) Silva,Ana Elizabete (1) Tajara,Eloiza Helena (1) Mais... Palavra-chave CCND1 (2) CDKN1A (1) Chromosome territories (1) Epigenetics (1) Esophageal carcinoma (1) GADD45A (1) Gastric cancer (1) HER-2/neu (1) Snake venom (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells J. Venom. Anim. Toxins incl. Trop. Dis. Machado,Ana Rita Thomazela; Aissa,Alexandre Ferro; Ribeiro,Diego Luis; Ferreira Jr.,Rui Seabra; Sampaio,Suely Vilela; Antunes,Lusânia Maria Greggi. Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carcinoma has increased worldwide, and the aberrant DNA methylation of liver cells is a common mechanism to promote hepatic tumorigenesis. Moreover, tumor microenvironment plays a major role in neoplastic transformation. To elucidate the molecular mechanisms responsible for the cytotoxic effects of SV-LAAO in human cancer cells, this study aimed to evaluate the cytotoxicity and the alterations in DNA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Epigenetics; GADD45A; CCND1; CDKN1A. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100305 Peripheral position of CCND1 and HER-2/neu oncogenes within chromosome territories in esophageal and gastric cancers non-related to amplification and overexpression Genet. Mol. Biol. Bizari,Lucimari; Tajara,Eloiza Helena; Silva,Ana Elizabete. Interphase chromosomes have been shown to occupy discrete regions of the nucleus denominated chromosome territories (CTs), their active genes being preferentially positioned on the surfaces of these CTs, where they are accessible to transcriptional machinery. By means of FISH (Fluorescence in situ Hybridization), we analyzed the CCND1 and HER-2/neu gene positions within the CTs and their relationship with gene amplification and protein over-expression in esophageal and gastric cancers. The CCND1 and HER-2/Neu genes were more often positioned at the periphery (mean frequency of 60%-83%) of the CTs in tumor tissues of the esophagus and stomach. Moreover, this positioning revealed no association with either gene amplification or the protein over-expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCND1; HER-2/neu; Chromosome territories; Esophageal carcinoma; Gastric cancer. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200006 Registros recuperados: 2 Primeira ... 1 ... Última

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